目錄:愛必信（上海）生物科技有限公司>>生化試劑>>小分子化合物>> abs47026943Gemcitabine
| 參考價(jià) | 85 |
參考價(jià)：￥ 85
10mg
CAS:95058-81-4 純度:＞98% 分子量:263.2 分子式:C9H11F2N3O4 供貨周期:現(xiàn)貨 規(guī)格:10mg 貨號(hào):abs47026943 應(yīng)用領(lǐng)域:化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 主要用途:is a nucleoside metabolic inhibitor in
>| 10mg | 85元 | 999mg可售 |
更新時(shí)間：2025-11-17 10:45:09瀏覽次數(shù)：1215評(píng)價(jià)
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| CAS | 95058-81-4 | 純度 | ＞98% |
|---|---|---|---|
| 分子量 | 263.2 | 分子式 | C9H11F2N3O4 |
| 供貨周期 | 現(xiàn)貨 | 規(guī)格 | 10mg |
| 貨號(hào) | abs47026943 | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
| 主要用途 | is a nucleoside metabolic inhibitor in |
| 產(chǎn)品描述 | |
| 描述 | Gemcitabine is a nucleoside metabolic inhibitor in PANC1（IC50=50 nM）, MIAPaCa2（IC50=40 nM）, BxPC3（IC50=18 nM） and Capan2 cells（IC50=12 nM）. |
| 純度 | ＞98% |
| 儲(chǔ)存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | 吉西他濱；NSC 613327；LY188011 |
| 外觀 | 白色至淺黃色粉末 |
| 可溶性/溶解性 | DMSO : 15 mg/mL (56.99 mM) |
| 生物活性 | |
| 靶點(diǎn) | DNA_RNA Synthesis |
| In vitro(體外研究) | MTS assay demonstrates that Gemcitabine at 15 nM, indole-3-carbinol (I3C) at 50 μM and the combination does not affect hTERT-HPNE cell viability. However, treatment with Gemcitabine at 15 nM, I3C at 50 μM and the combination results in 31%, 19% and 72% cell death of BxPC-3 cells, respectively. |
| In vivo(體內(nèi)研究) | Treatment of the LSL-KrasG12D/+; LSL-Trp53R172H; Pdx-1-Cre mice with either Gemcitabine (50 mg/kg, i.p.) or the combination DMAPT/Gemcitabine significantly increased the median survival time by more than 30 days compared to the placebo group (254.5 or 255 days vs. 217.5 days, respectively). Gemcitabine can be administered via endotracheal spray in rats without marked toxicity with a maximum tolerated dose of 4 mg/kg once a week for 9 weeks. The toxicity of Gemcitabine is lower via lung than oral administration at dosages of 2, 4, and 6 mg/kg. |
| 參考文獻(xiàn) | |
| 參考文獻(xiàn) |
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| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | CancerCancer Metabolism CancerTumor biomarkers CancerTumor immunology Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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