目錄:愛必信（上海）生物科技有限公司>>生化試劑>>小分子化合物>> abs47028220BMY 7378 dihydrochloride 21102-95-4
| 參考價 | ￥399-￥950 |
參考價：￥399 ~ ￥950
10mg 50mg
CAS:21102-95-4 純度:98% 分子量:458.42 分子式:C22H33Cl2N3O3 供貨周期:現(xiàn)貨 規(guī)格:10mg 貨號:abs47028220 應(yīng)用領(lǐng)域:化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 主要用途:is a 5-HT1A receptor weak partial agonis
>| 10mg | 399元 | 999mg可售 |
| 50mg | 950元 | 999mg可售 |
更新時間：2026-01-23 14:01:34瀏覽次數(shù)：843評價
聯(lián)系我們時請說明是化工儀器網(wǎng)上看到的信息，謝謝!
| CAS | 21102-95-4 | 純度 | 98% |
|---|---|---|---|
| 分子量 | 458.42 | 分子式 | C22H33Cl2N3O3 |
| 供貨周期 | 現(xiàn)貨 | 規(guī)格 | 10mg |
| 貨號 | abs47028220 | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
| 主要用途 | is a 5-HT1A receptor weak partial agonis |
BMY 7378 dihydrochloride 21102-95-4
| 產(chǎn)品描述 | |
| 描述 | BMY-7,378 is a 5-HT1A receptor weak partial agonist/antagonist and α1D-adrenergic receptor antagonist. |
| 純度 | 98% |
| 儲存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | BMY 7378 2HCl |
| 外觀 | white solid |
| 可溶性/溶解性 | DMSO : 85 mg/mL (185.4 mM) Ethanol : 16 mg/mL (34.9 mM) Water : 84 mg/mL (183.2 mM) |
| 生物活性 | |
| 靶點 | 5-HT1A,α1D-adrenoceptor,Dopamine D2 receptor,α2C-adrenoceptor ,5-HT1C,, |
| In vitro(體外研究) | BMY 7378 shows 10-fold selectivity for α2C-adrenoceptors over other α2-adrenoceptors with pKi of 6.54. BMY 7378 is selective for the α1D-adrenoceptor subtype (PKi: hamster α1b-adrenoceptor 6.2, human α1b-adrenoceptor 7.2; bovine α1c-adrenoceptor 6.1, human α1c-adrenoceptor 6.6; rat α1d-adrenoceptor 8.2, human α1d-adrenoceptor 9.4 BMY 7378 at concentration of 1 nM to 30 nM elicits inhibitory effects in a concentration-dependent manner in the rat dorsal raphe nucleus. |
| In vivo(體內(nèi)研究) | BMY 7378 (pA2 of 8.67) is approximately 100 times more potent than yohimbine (pA2 of 6.62) against contractions to noradrenaline in rat aorta. BMY 7378 (pA2 of 6.48) is approximately 10 times less potent than yohimbine (pA2 of 7.56) at antagonizing the contractile response to noradrenaline in human saphenous vein (α2C-adrenoceptor). BMY 7378 dose dependently (0.25-5 mg/kg s.c.) reduces the undetectable levels forepaw treading and head weaving induced by 8-OH-DPAT (0.75 mg/kg s.c.) in rats. BMY 7378 causes a marked and dose-dependent (0.01-1.0 mg/kg s.c.) decrease of 5-HT release in ventral hippocampus of the anaesthetized rat as detected by brain microdialysis in rats. |
| 參考文獻(xiàn) | |
| 參考文獻(xiàn) |
| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | Cardiovascular Drug DiscoverySmall Molecule DrugLead Compound Discovery |
(空格分隔,最多3個,單個標(biāo)簽最多10個字符)
10
化工儀器網(wǎng)