目錄:愛必信（上海）生物科技有限公司>>生化試劑>>小分子化合物>> abs47028234Alvelestat 848141-11-7
| 參考價 | ￥1235-￥3295 |
參考價：￥1235 ~ ￥3295
10mg 50mg
CAS:848141-11-7 分子量:545.53 分子式:C25H22F3N5O4S 供貨周期:現(xiàn)貨 規(guī)格:10mg 貨號:abs47028234 應(yīng)用領(lǐng)域:化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 主要用途:is an oral, highly selective inhibitor
>| 10mg | 1235元 | 999mg可售 |
| 50mg | 3295元 | 999mg可售 |
更新時間：2026-01-26 09:20:14瀏覽次數(shù)：904評價
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| CAS | 848141-11-7 | 分子量 | 545.53 |
|---|---|---|---|
| 分子式 | C25H22F3N5O4S | 供貨周期 | 現(xiàn)貨 |
| 規(guī)格 | 10mg | 貨號 | abs47028234 |
| 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 | 主要用途 | is an oral, highly selective inhibitor |
Alvelestat 848141-11-7
| 產(chǎn)品描述 | |
| 描述 | Alvelestat (AZD9668) is an oral, highly selective inhibitor of neutrophil elastase (NE) with IC50 and Ki of 12 nM and 9.4 nM, at least 600-fold more selective over other serine proteases. Phase 2. |
| 純度 | 98% |
| 儲存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | AZD9668 |
| 外觀 | White Solid |
| 可溶性/溶解性 | DMSO : 40 mg/mL (73.32 mM) |
| 生物活性 | |
| 靶點 | neutrophil elastase ,neutrophil elastase |
| In vitro(體外研究) | AZD9668 inhibits plasma NE activity in zymosan-stimulated whole blood, and also inhibits NE activity on the surface of stimulated polymorphonuclear cells and in the supernatant of primed, stimulated cells. |
| In vivo(體內(nèi)研究) | In mice and rats, AZD9668 (p.o.) prevents human NE-induced lung injury. In a mouse model of smoke-induced airway inflammation, AZD9668 significantly reduces the number of BAL neutrophils and BAL IL-1β. In a guinea pig chronic smoke model, AZD9668 prevents airspace enlargement and small airway wall remodeling in guinea pigs in response to chronic tobacco smoke exposure. |
| 參考文獻 | |
| 參考文獻 |
| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | Proteolysis / UbiquitinProteasome / Ubiquitin Signal TransductionCytoskeleton / ECMExtracellular MatrixECM ProteinsCollagen Signal TransductionCytoskeleton / ECMExtracellular MatrixECM ProteinsElastin Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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