目錄:愛必信（上海）生物科技有限公司>>生化試劑>>小分子化合物>> abs47028242Pemetrexed Disodium Hydrate 357166-30-4
| 參考價 | ￥485-￥1090 |
參考價：￥485 ~ ￥1090
2mg 10mg 50mg >
CAS:357166-30-4 純度:98% 分子量:516.42 分子式:C20H21N5O6.5/2H2O.2Na 供貨周期:現(xiàn)貨 規(guī)格:2mg 貨號:abs47028242 應(yīng)用領(lǐng)域:化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 主要用途:is a novel antifolate and antimetabolite
>| 2mg | 485元 | 999mg可售 |
| 10mg | 874元 | 999mg可售 |
| 50mg | 985元 | 999mg可售 |
更新時間：2026-01-26 09:42:18瀏覽次數(shù)：789評價
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| CAS | 357166-30-4 | 純度 | 98% |
|---|---|---|---|
| 分子量 | 516.42 | 分子式 | C20H21N5O6.5/2H2O.2Na |
| 供貨周期 | 現(xiàn)貨 | 規(guī)格 | 2mg |
| 貨號 | abs47028242 | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
| 主要用途 | is a novel antifolate and antimetabolite |
Pemetrexed Disodium Hydrate 357166-30-4
| 產(chǎn)品描述 | |
| 描述 | Pemetrexed Disodium Hydrate is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively. |
| 純度 | 98% |
| 儲存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 可溶性/溶解性 | DMSO:<1 mg/mL (<1 mM) |
| 生物活性 | |
| 靶點 | TS,DHFR,GARFT |
| In vitro(體外研究) | Pemetrexed disodium shows the antiproliferative activity in CCRF-CEM leukemia, GC3/C1 colon carcinoma, and HCT-8 ileocecal carcinoma cells with IC50 of 25 nM, 34 nM and 220 nM, respectively. A recent study shows that cisplatin plus Pemetrexed combined with SOCS-1 gene delivery shows the antitumor effect by inhibition of cell proliferation, invasiveness, and induction of apoptosis in MPM cells infected with adenovirus-expressing SOCS-1 vector. |
| In vivo(體內(nèi)研究) | In the human H460 non-small cell lung carcinoma xenograft, Pemetrexed disodium produces a duration-dependent tumor growth delay (TGD). |
| 參考文獻(xiàn) | |
| 參考文獻(xiàn) |
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| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | Signal TransductionMetabolism Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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