目錄:愛必信（上海）生物科技有限公司>>生化試劑>>小分子化合物>> abs47028250GNE-0877 1374828-69-9
| 參考價(jià) | ￥1189-￥6946 |
參考價(jià)：￥1189 ~ ￥6946
2mg 5mg 10mg >
CAS:1374828-69-9 純度:98% 分子量:339.32 分子式:C14H16F3N7 供貨周期:現(xiàn)貨 規(guī)格:2mg 貨號(hào):abs47028250 應(yīng)用領(lǐng)域:化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 主要用途:is a highly potent and selective
>| 2mg | 1189元 | 999mg可售 |
| 5mg | 1880元 | 999mg可售 |
| 10mg | 3311元 | 999mg可售 |
更新時(shí)間：2026-01-26 13:31:01瀏覽次數(shù)：970評(píng)價(jià)
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| CAS | 1374828-69-9 | 純度 | 98% |
|---|---|---|---|
| 分子量 | 339.32 | 分子式 | C14H16F3N7 |
| 供貨周期 | 現(xiàn)貨 | 規(guī)格 | 2mg |
| 貨號(hào) | abs47028250 | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
| 主要用途 | is a highly potent and selective |
GNE-0877 1374828-69-9
| 產(chǎn)品描述 | |
| 描述 | GNE-0877 is a highly potent and selective leucine-rich repeat kinase 2 (LRRK2) inhibitor with Ki of 0.7 nM. |
| 純度 | 98% |
| 儲(chǔ)存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 可溶性/溶解性 | DMSO:67 mg/mL (197.45 mM) |
| 生物活性 | |
| 靶點(diǎn) | LRRK2 |
| In vitro(體外研究) | GNE-0877 significantly inhibits LRRK2 cellular activity with IC50 of 3 nM, and shows low turnover in human liver microsomes and hepatocytes. Besides, GNE-0877 is also a reversible CYP1A2 inhibitor with IC50 of 0.7 μM. |
| In vivo(體內(nèi)研究) | In vivo, GNE-0877 shows good oral bioavailability and brain penetration. GNE-0877 inhibits in vivo LRRK2 Ser1292 autophosphorylation in BAC transgenic mice expressing human LRRK2 protein with the G2019S Parkinson’s disease mutation. |
| 參考文獻(xiàn) | |
| 參考文獻(xiàn) |
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| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | NeuroscienceDiseases NeuroscienceNeurology processNeurodegenerative diseaseParkinson's diseaseSynuclein Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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