目錄:愛必信（上海）生物科技有限公司>>生化試劑>>小分子化合物>> abs47028258Cabotegravir 1051375-10-0
| 參考價(jià) | ￥450-￥1450 |
參考價(jià)：￥450 ~ ￥1450
10mg 50mg
CAS:1051375-10-0 純度:98% 分子量:405.35 分子式:C19H17F2N3O5 供貨周期:現(xiàn)貨 規(guī)格:10mg 貨號(hào):abs47028258 應(yīng)用領(lǐng)域:化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 主要用途:is a long-acting HIV integrase inhibito
>| 10mg | 450元 | 999mg可售 |
| 50mg | 1450元 | 999mg可售 |
更新時(shí)間：2026-01-26 13:50:53瀏覽次數(shù)：878評(píng)價(jià)
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| CAS | 1051375-10-0 | 純度 | 98% |
|---|---|---|---|
| 分子量 | 405.35 | 分子式 | C19H17F2N3O5 |
| 供貨周期 | 現(xiàn)貨 | 規(guī)格 | 10mg |
| 貨號(hào) | abs47028258 | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
| 主要用途 | is a long-acting HIV integrase inhibito |
Cabotegravir 1051375-10-0
| 產(chǎn)品描述 | |
| 描述 | Cabotegravir (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor against a broad range of HIV subtypes, and inhibits the HIV-1 integrase catalyzed strand transfer reaction with IC50 of 3.0 nM. Phase 2. |
| 純度 | 98% |
| 儲(chǔ)存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | 卡博特韋; GSK-1265744； S/GSK1265744 |
| 外觀 | White off off white crystalline powder |
| 可溶性/溶解性 | DMSO : 16.67 mg/mL (41.12 mM; Need ultrasonic) |
| 生物活性 | |
| 靶點(diǎn) | HIV integrase |
| In vitro(體外研究) | GSK1265744 inhibits HIV replication with EC50 of 0.22 nM and 0.34-1.3 nM against HIV-1 Ba-L and NL432, respectively. GSK1265744 produces cytotoxicity with CC50 of 6.4, 5.0, 9.2, and 13 μM in proliferating IM-9, U-937, MT-4, and Molt-4 cell lines, respectively. |
| In vivo(體內(nèi)研究) | GSK1265744 (50 mg/kg) treatment protects rhesus macaques against three high-dose SHIV challenges. |
| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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