目錄:愛必信（上海）生物科技有限公司>>生化試劑>>小分子化合物>> abs47028259Cerdulatinib (PRT062070, PRT2070) 1369761-01-2
| 參考價 | ￥437-￥1989 |
參考價：￥437 ~ ￥1989
2mg 5mg 10mg >
CAS:1369761-01-2 純度:98% 分子量:482 分子式:C20H28ClN7O3S 供貨周期:現(xiàn)貨 規(guī)格:2mg 貨號:abs47028259 應(yīng)用領(lǐng)域:化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 主要用途:is an oral active
>| 2mg | 437元 | 999mg可售 |
| 5mg | 776元 | 999mg可售 |
| 10mg | 1164元 | 999mg可售 |
更新時間：2026-01-26 13:53:52瀏覽次數(shù)：1024評價
聯(lián)系我們時請說明是化工儀器網(wǎng)上看到的信息，謝謝!
| CAS | 1369761-01-2 | 純度 | 98% |
|---|---|---|---|
| 分子量 | 482 | 分子式 | C20H28ClN7O3S |
| 供貨周期 | 現(xiàn)貨 | 規(guī)格 | 2mg |
| 貨號 | abs47028259 | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
| 主要用途 | is an oral active |
Cerdulatinib (PRT062070, PRT2070) 1369761-01-2
| 產(chǎn)品描述 | |
| 描述 | Cerdulatinib (PRT-062070) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and Syk, respectively. Also inhibits 19 other tested kinases with IC50 less than 200 nM. |
| 純度 | 98% |
| 儲存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 可溶性/溶解性 | DMSO:43 mg/mL warmed (89.21 mM) |
| 生物活性 | |
| 靶點 | TYK2 ,MST1 ,ARK5 ,MLK1 ,Fms |
| In vitro(體外研究) | In human whole blood from normal donors, Cerdulatinib affects BCR-mediated B-cell activation by dual inhibition of SYK and JAK. As a dual SYK/JAK inhibitor, Cerdulatinib significantly reduces cell viability in a subset of NHL cell lines, and induces apoptosis in BCR-signaling competent NHL cell lines. |
| In vivo(體內(nèi)研究) | In a rat collagen-induced arthritis model, Cerdulatinib (5 mg/kg p.o.) significantly improves inflammatory infiltrate within the synovium and the integrity of the articular cartilage. In addition, Cerdulatinib also blocks BCR-induced B-cell activation and splenomegaly in mice. |
| 參考文獻 | |
| 參考文獻 |
|
| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | MicrobiologyOrganismVirusDNA VirusssRNA positive strand virusSARS Coronavirus Signal TransductionProtein PhosphorylationTyrosine KinasesOther Drug DiscoverySmall Molecule DrugLead Compound Discovery |
10
化工儀器網(wǎng)