目錄:愛必信（上海）生物科技有限公司>>生化試劑>>小分子化合物>> abs810462CO1686 1374640-70-6
| 參考價(jià) | ￥947-￥5874 |
參考價(jià)：￥947 ~ ￥5874
5mg 10mg 50mg >
CAS:1374640-70-6 純度:＞98% 分子量:555.55 分子式:C27H28F3N7O3 供貨周期:現(xiàn)貨 規(guī)格:5mg 貨號(hào):abs810462 應(yīng)用領(lǐng)域:化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 主要用途:is a novel, irreversible and orally deli
>| 5mg | 947元 | 999mg可售 |
| 10mg | 1285元 | 999mg可售 |
| 50mg | 4466元 | 999mg可售 |
更新時(shí)間：2026-02-05 09:20:17瀏覽次數(shù)：1069評價(jià)
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| CAS | 1374640-70-6 | 純度 | ＞98% |
|---|---|---|---|
| 分子量 | 555.55 | 分子式 | C27H28F3N7O3 |
| 供貨周期 | 現(xiàn)貨 | 規(guī)格 | 5mg |
| 貨號(hào) | abs810462 | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
| 主要用途 | is a novel, irreversible and orally deli |
CO1686 1374640-70-6
| 產(chǎn)品描述 | |
| 描述 | CO-1686 is a novel, irreversible and orally delivered kinase inhibitor that specifically targets the mutant forms of EGFR including T790M(IC50=21 nM). |
| 純度 | >98% |
| 儲(chǔ)存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | Rociletinib, AVL-301; CNX-419,co 1686,co1686 |
| 外觀 | Powder |
| 可溶性/溶解性 | DMSO 100 mg/mL (180.0 mM) |
| 生物活性 | |
| 靶點(diǎn) | EGFR (L858R/T790M) ,EGFR (wt) |
| In vitro(體外研究) | CO-1686 inhibits p-EGFR with IC50 ranging from 62 to 187 nM in the mutant EGFR–expressing cells, while inhibits EGFR phosphorylation with IC50 of > 2,000 nM in the three WT EGFR–expressing cells. CO-1686 selectively inhibits growth of NSCLC cells expressing mutant EGFR with GI50 ranging from 7 to 32 nM, and induces apoptosis. CO-1686–resistant NSCLC cell lines exhibits signs of epithelial-mesenchymal transition and increased sensitivity to AKT inhibitors. |
| In vivo(體內(nèi)研究) | CO-1686 causes dose-dependent and significant tumor growth inhibition in all EGFR-mutant models as well as human EGFRL858R- and EGFRL858R/T790M-expressing transgenic mice. |
| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | CancerGrowth factorsEGF CancerOncoproteins/suppressorsOncoproteinsGrowth factor receptors CancerSignal transductionProtein phosphorylationTyrosine kinasesReceptor tyrosine kinases CancerTumor biomarkersReceptors Cell CycleCell differentiation MicrobiologyOrganismVirusDNA VirusssRNA positive strand virusSARS Coronavirus NeuroscienceDevelopment NeuroscienceProcesses Signal TransductionGrowth Factors/HormonesEGF Signal TransductionProtein PhosphorylationTyrosine KinasesReceptor Tyrosine Kinases Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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