目錄:愛必信（上海）生物科技有限公司>>生化試劑>>小分子化合物>> abs810498RG108 48208-26-0
| 參考價 | ￥604-￥6899 |
參考價：￥604 ~ ￥6899
5mg 10mg 50mg >
CAS:48208-26-0 純度:＞98% 分子量:334.33 分子式:C19H14N2O4 供貨周期:現(xiàn)貨 規(guī)格:5mg 貨號:abs810498 應用領(lǐng)域:化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 主要用途:is an inhibitor of DNA methyltransferase
>| 5mg | 604元 | 999mg可售 |
| 10mg | 935元 | 999mg可售 |
| 50mg | 3833元 | 999mg可售 |
更新時間：2026-02-05 09:44:18瀏覽次數(shù)：1171評價
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| CAS | 48208-26-0 | 純度 | ＞98% |
|---|---|---|---|
| 分子量 | 334.33 | 分子式 | C19H14N2O4 |
| 供貨周期 | 現(xiàn)貨 | 規(guī)格 | 5mg |
| 貨號 | abs810498 | 應用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
| 主要用途 | is an inhibitor of DNA methyltransferase |
RG108 48208-26-0
| 產(chǎn)品描述 | |
| 描述 | RG108 is an inhibitor of DNA methyltransferase with IC50 of 115 nM, does not cause trapping of covalent enzymes. |
| 純度 | >98% |
| 儲存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | RG-108，RG 108，N-Phthalyl-L-tryptophan |
| 外觀 | Powder |
| 可溶性/溶解性 | Ethanol ：33.4 mg/mL (100 mM) DMSO ：33.4 mg/mL (100 mM) |
| 生物活性 | |
| 靶點 | DNA methyltransferase |
| In vitro(體外研究) | RG108 effectively blocks DNA methyltransferases in vitro and does not cause covalent enzyme trapping in human cell lines. Incubation of cells with low micromolar concentrations of RG108 results in significant demethylation of genomic DNA without any detectable toxicity. Intriguingly, RG108 causes demethylation and reactivation of tumor suppressor genes, but it does not affect the methylation of centromeric satellite sequences. In another study, the synthesis and in vitro analysis of a biotinylated RG108 conjugate is investigated to evaluate the interactions with DNA methyltransferase enzymes. In a recent study, it is shown RG108 can significantly reduce the DNA methyltransferases activity in SM derived iPS cells as compared to the native SMs. |
| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | Epigenetics Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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