Human TNF beta （Lymphotoxin-alpha） is a 22 kDa cytokine with 205 amino acid residues. TNF beta belongs to tumor necrosis factor （TNF） superfamily as TNF alpha. Binding to lymphotoxin-β receptor （LtβR）, canonical and non-canonical NF-κB signal pathway will be activated. TNF beta is related to apoptosis and inflammatory signals